Information for Medical Professionals

Bone-turnover markers 'can play a role in fracture healing innovations'

The use of bone-turnover markers in the field of fracture healing is an important one, it has been claimed.

According to researchers behind the Bone-turnover Markers in Fracture Healing study published in the Journal of Bone and Joint Surgery, despite the fact that bone-turnover markers vary throughout fracture repair, this does not mean they should be ignored.

The researchers behind the paper claimed that "short-term biological variability, the relatively low bone specificity exerted" and "the influence of the host's metabolism on their concentration, produce considerable intra- and inter-individual variability in their interpretation".

However, they added: "Despite this, the possible role of bone-turnover markers in the assessment of progression to union, the risks of delayed or non-union and the impact of innovations to accelerate fracture healing must not be ignored."

They claimed that their widespread use in daily clinical assessment has not only been helpful in understanding the pathology of conditions such as osteoporosis, but in the understanding of the conditions onset and resolution of treatment.

Recent research conducted at the University Hospital Basel's Department of Internal Medicine, in Switzerland, showed that there are currently no reliable markers for discerning between infectious and non-infectious postoperative fever.

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